Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 5.728


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7



Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_101852028 19.502 NM_175929
FGF14
fibroblast growth factor 14
chr8_-_122722674 18.883 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_168898898 16.271 PRRX1
paired related homeobox 1
chr7_-_41709191 15.744 NM_002192
INHBA
inhibin, beta A
chr11_+_101488380 15.485 NM_001195045
YAP1
Yes-associated protein 1
chr9_-_8723893 13.536 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr3_+_174598937 12.876 NM_014932
NLGN1
neuroligin 1
chr3_-_55489973 12.605 WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_115960807 12.451 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_-_27108826 11.393 NM_006735
HOXA2
homeobox A2
chr5_+_174084137 10.619 NM_002449
MSX2
msh homeobox 2
chrX_-_33267646 10.428 NM_000109
DMD
dystrophin
chr14_+_51025604 10.220 NM_001042481
FRMD6
FERM domain containing 6
chr9_-_116920232 9.663 NM_002160
TNC
tenascin C
chr10_+_69539255 9.599 NM_032578
MYPN
myopalladin
chr5_+_59819761 9.431 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr7_-_83662152 9.382 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_-_138935359 9.278 NM_020464
NHSL1
NHS-like 1
chr18_+_30544193 9.218 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr18_+_30427279 9.126 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr7_+_113842284 8.964 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr20_+_11846536 8.951 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr6_+_12825818 8.916 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr10_-_118887801 8.870 NM_001112704
NM_199131
VAX1

ventral anterior homeobox 1

chr3_-_21767819 8.707 NM_024697
ZNF385D
zinc finger protein 385D
chr4_+_160408447 8.637 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr4_-_23500706 8.606 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr7_-_27149750 8.576 NM_019102
HOXA5
homeobox A5
chr5_-_59819642 8.443 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_20682541 8.225


chr8_+_70541631 8.193 SULF1
sulfatase 1
chr10_+_24795446 8.177 KIAA1217
KIAA1217
chr10_+_24795465 8.093 KIAA1217
KIAA1217
chr17_-_46479127 8.060 SPAG9
sperm associated antigen 9
chr14_-_94306104 8.058 NM_173849
GSC
goosecoid homeobox
chr15_+_55298908 7.871 NM_207040
TCF12
transcription factor 12
chr18_-_44723116 7.806 NM_001190823
SMAD7
SMAD family member 7
chr9_+_674193 7.726


chr8_+_70541412 7.725 NM_001128204
NM_015170
SULF1

sulfatase 1

chr7_-_27171600 7.649 HOXA9
homeobox A9
chr5_+_127012611 7.588 NM_001048252
CTXN3
cortexin 3
chr3_-_64186151 7.475 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr5_-_124108672 7.264 NM_020747
ZNF608
zinc finger protein 608
chr7_+_113842470 7.233 FOXP2
forkhead box P2
chr7_-_27171673 7.208 NM_152739
HOXA9
homeobox A9
chr1_+_213245507 7.197 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr13_-_45323757 7.147 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr9_+_102380156 7.135 NM_001018116
MURC
muscle-related coiled-coil protein
chr7_+_113842407 7.060 FOXP2
forkhead box P2
chr11_-_128567302 7.026 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr16_+_7322751 7.003 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr10_-_29963906 6.950 NM_021738
SVIL
supervillin
chr1_-_214963279 6.933 NM_001438
ESRRG
estrogen-related receptor gamma
chr8_-_72431274 6.898 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_92671005 6.850 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_116272911 6.798 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_27171648 6.790 HOXA9
homeobox A9
chr3_-_156876798 6.759 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr16_-_49742651 6.750 NM_002968
SALL1
sal-like 1 (Drosophila)
chr3_+_116824840 6.635 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr5_-_1935764 6.608 NM_016358
IRX4
iroquois homeobox 4
chr4_-_152366970 6.581 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_+_81544432 6.570 LPHN2
latrophilin 2
chr2_-_183095308 6.564 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr13_-_37070862 6.562 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr13_-_85271329 6.393 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr2_+_33213111 6.362 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr20_+_19903778 6.337 RIN2
Ras and Rab interactor 2
chr6_-_152744022 6.302 SYNE1
spectrin repeat containing, nuclear envelope 1
chr14_+_85069217 6.188


chr21_-_34820916 6.152 NM_203418
RCAN1
regulator of calcineurin 1
chr6_-_116488458 6.149 NM_002031
FRK
fyn-related kinase
chr2_+_202379442 6.131 NM_139158
CDK15
cyclin-dependent kinase 15
chr9_-_94226380 6.109 NM_005014
OMD
osteomodulin
chr3_+_158637273 6.098 NM_002852
PTX3
pentraxin 3, long
chr13_+_75232797 6.048 NM_015842
LMO7
LIM domain 7
chr3_-_11585264 6.037 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr3_+_161040439 6.029 SCHIP1
schwannomin interacting protein 1
chr7_+_134226727 6.003 CALD1
caldesmon 1
chr20_+_31613800 5.984 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr3_-_110155237 5.949 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr3_+_137224266 5.944 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr2_+_36777336 5.882 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr5_+_152850276 5.819 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr15_-_31147376 5.782 NM_001103184
FMN1
formin 1
chr5_-_59100091 5.771 PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_11598829 5.760 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr5_-_59100194 5.741 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_53996597 5.710 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr9_-_72673753 5.696 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr7_+_18501876 5.690 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr16_+_85169615 5.654 NM_005250
FOXL1
forkhead box L1
chr2_-_164300758 5.652 NM_018086
FIGN
fidgetin
chr7_+_134114912 5.636 CALD1
caldesmon 1
chr3_-_62334229 5.608 NM_018008
FEZF2
FEZ family zinc finger 2
chr9_+_108665168 5.581 NM_021224
ZNF462
zinc finger protein 462
chr11_-_27679617 5.578 NM_170733
BDNF
brain-derived neurotrophic factor
chr4_+_119174947 5.555 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr12_+_79362256 5.520 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr12_-_90100733 5.518 NM_001920
DCN
decorin
chr10_-_116434364 5.473 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_-_87989291 5.408 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr6_+_108593907 5.312 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_-_27604656 5.265 WASF2
WAS protein family, member 2
chr10_-_29963847 5.247


chr5_+_131437383 5.213 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_-_133145539 5.211 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_+_175406685 5.136 FAM5B
family with sequence similarity 5, member B
chr12_-_16650687 5.119 LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_117955890 5.087 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr10_+_52420936 5.069 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr6_+_136214495 5.069 NM_018945
PDE7B
phosphodiesterase 7B
chr13_+_100902942 5.057 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr3_-_115825742 5.045 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr18_+_64616296 5.015 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr4_-_110443247 4.997 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr8_-_15140162 4.992 NM_139167
SGCZ
sarcoglycan, zeta
chr12_-_16650697 4.968 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_69895310 4.941 NM_001184967
MITF
microphthalmia-associated transcription factor
chr6_-_56615544 4.924 NM_001723
NM_015548
DST

dystonin

chr4_+_41309668 4.915 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_41309690 4.913 LIMCH1
LIM and calponin homology domains 1
chr10_+_68355797 4.899 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr8_-_13416554 4.893 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr5_+_155686333 4.890 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr6_-_101018271 4.874 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chrX_+_102471769 4.863 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr2_+_36777406 4.853 VIT
vitrin
chrX_+_28515479 4.834 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chrX_-_31436335 4.827 NM_004014
DMD
dystrophin
chrX_+_135106578 4.811 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr10_-_14090459 4.809 FRMD4A
FERM domain containing 4A
chr4_+_41309482 4.803 LIMCH1
LIM and calponin homology domains 1
chr14_-_91483325 4.712 FBLN5
fibulin 5
chr7_-_83116414 4.699 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_-_153493133 4.699 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr2_-_55090759 4.693 NM_007008
RTN4
reticulon 4
chr3_-_188935363 4.688 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr11_+_131285747 4.641 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr7_-_27153892 4.638 NM_024014
HOXA6
homeobox A6
chr21_+_29439768 4.618 C21orf7
chromosome 21 open reading frame 7
chr3_-_139315011 4.616 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr12_+_50633430 4.610 NM_020327
ACVR1B
activin A receptor, type IB
chr3_+_25445071 4.589 RARB
retinoic acid receptor, beta
chr3_+_115099007 4.549 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr22_-_34566210 4.538 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_189752575 4.483 NM_000393
COL5A2
collagen, type V, alpha 2
chr8_+_70567634 4.450 SULF1
sulfatase 1
chr10_+_86174665 4.424 FAM190B
family with sequence similarity 190, member B
chr3_-_150578207 4.420 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_+_88268845 4.388 LOC100131490
hypothetical LOC100131490
chr2_-_160764819 4.385 NM_000888
ITGB6
integrin, beta 6
chrX_-_19598912 4.378 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr7_-_92615593 4.374 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chrX_-_138552517 4.329 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr4_-_41579325 4.328


chr7_+_134114701 4.319 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr4_+_81325447 4.300 NM_020226
PRDM8
PR domain containing 8
chr6_-_127882192 4.290 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr5_+_66160359 4.282 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_+_84198015 4.271 NM_006982
ALX1
ALX homeobox 1
chr3_+_161040343 4.253 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr11_-_85107569 4.252 NM_206929
SYTL2
synaptotagmin-like 2
chr8_+_70567581 4.245 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr5_-_169340321 4.236 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr20_-_1298493 4.227 FKBP1A
FK506 binding protein 1A, 12kDa
chr4_-_159312973 4.187 FAM198B
family with sequence similarity 198, member B
chr17_+_38719371 4.167 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr7_-_27120015 4.158 HOXA3
homeobox A3
chr12_-_90100710 4.157 DCN
decorin
chr5_-_20024050 4.144 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chrX_+_77889861 4.139 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr3_-_79899748 4.133 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_71262426 4.125 FOXP1
forkhead box P1
chr1_-_191422346 4.072 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_+_134114957 4.062 CALD1
caldesmon 1
chr14_-_79748273 4.039 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr12_-_90100679 4.035 DCN
decorin
chr11_+_26972244 4.032 FIBIN
fin bud initiation factor homolog (zebrafish)
chr4_+_3341521 4.011 NM_198227
RGS12
regulator of G-protein signaling 12
chr3_-_49372584 3.995 RHOA
ras homolog gene family, member A
chr3_+_89239494 3.990 EPHA3
EPH receptor A3
chr17_+_36515166 3.987 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr10_-_33663305 3.981 NRP1
neuropilin 1
chr2_+_66516196 3.978 MEIS1
Meis homeobox 1
chr2_-_190635566 3.956 NM_005259
MSTN
myostatin
chr22_-_34566276 3.955 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_150578148 3.937 TM4SF1
transmembrane 4 L six family member 1
chr12_+_32546243 3.916 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_-_92670764 3.910 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_+_183302105 3.908 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_108579270 3.882 NM_001146
ANGPT1
angiopoietin 1
chr6_+_21701942 3.879 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr6_+_121798443 3.878 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr8_-_93144039 3.878


chrX_-_33139349 3.875 NM_004006
DMD
dystrophin
chr20_+_19818209 3.853 NM_018993
RIN2
Ras and Rab interactor 2
chr6_+_152053323 3.826 NM_001122742
ESR1
estrogen receptor 1
chr12_-_16649211 3.821 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_12996368 3.806 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 5.58e-33 GO:0032501 multicellular organismal process
1.51 1.06e-32 GO:0048731 system development
1.45 3.47e-32 GO:0007275 multicellular organismal development
1.46 5.59e-31 GO:0048856 anatomical structure development
1.40 1.76e-29 GO:0032502 developmental process
1.61 2.01e-21 GO:0007399 nervous system development
1.58 1.56e-19 GO:0009653 anatomical structure morphogenesis
1.50 8.49e-19 GO:0048513 organ development
1.44 1.43e-15 GO:0030154 cell differentiation
1.68 3.74e-15 GO:0022008 neurogenesis
1.42 7.77e-15 GO:0048869 cellular developmental process
1.69 1.35e-14 GO:0048699 generation of neurons
1.62 1.42e-13 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.77 1.05e-12 GO:0045893 positive regulation of transcription, DNA-dependent
1.73 1.60e-12 GO:0010628 positive regulation of gene expression
1.64 3.25e-12 GO:0009888 tissue development
1.72 3.36e-12 GO:0045595 regulation of cell differentiation
1.68 8.26e-12 GO:0010557 positive regulation of macromolecule biosynthetic process
1.60 8.34e-12 GO:0048468 cell development
1.70 9.50e-12 GO:0030182 neuron differentiation
1.59 3.37e-11 GO:0050793 regulation of developmental process
1.84 3.50e-11 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.70 4.85e-11 GO:0051254 positive regulation of RNA metabolic process
1.64 1.24e-10 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.08 1.68e-10 GO:0061061 muscle structure development
1.62 2.35e-10 GO:0051173 positive regulation of nitrogen compound metabolic process
1.66 2.94e-10 GO:0009790 embryo development
1.63 3.11e-10 GO:2000026 regulation of multicellular organismal development
1.59 4.24e-10 GO:0031328 positive regulation of cellular biosynthetic process
1.59 4.28e-10 GO:0009891 positive regulation of biosynthetic process
2.25 1.56e-09 GO:0007517 muscle organ development
1.70 2.73e-09 GO:0048666 neuron development
2.42 3.58e-09 GO:0045165 cell fate commitment
1.93 1.16e-08 GO:0060284 regulation of cell development
1.37 2.22e-08 GO:0003008 system process
1.72 2.51e-08 GO:0000904 cell morphogenesis involved in differentiation
1.65 3.33e-08 GO:0009887 organ morphogenesis
1.15 4.04e-08 GO:0050794 regulation of cellular process
2.41 5.30e-08 GO:0060537 muscle tissue development
2.04 7.34e-08 GO:0003002 regionalization
1.89 8.87e-08 GO:0001501 skeletal system development
1.64 9.46e-08 GO:0000902 cell morphogenesis
1.48 1.48e-07 GO:0009605 response to external stimulus
1.60 1.75e-07 GO:0030030 cell projection organization
1.69 1.96e-07 GO:0031175 neuron projection development
1.72 4.48e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
2.40 4.69e-07 GO:0014706 striated muscle tissue development
1.66 5.17e-07 GO:0007417 central nervous system development
1.94 5.57e-07 GO:0045596 negative regulation of cell differentiation
1.71 6.17e-07 GO:0051094 positive regulation of developmental process
1.26 6.18e-07 GO:0048518 positive regulation of biological process
1.59 6.91e-07 GO:0032989 cellular component morphogenesis
1.73 6.94e-07 GO:0007409 axonogenesis
1.13 7.12e-07 GO:0050789 regulation of biological process
1.71 7.53e-07 GO:0048812 neuron projection morphogenesis
1.39 9.89e-07 GO:0051239 regulation of multicellular organismal process
1.40 1.11e-06 GO:0009893 positive regulation of metabolic process
1.15 1.42e-06 GO:0050896 response to stimulus
1.82 1.45e-06 GO:0051093 negative regulation of developmental process
1.12 1.50e-06 GO:0065007 biological regulation
1.67 1.57e-06 GO:0072358 cardiovascular system development
1.67 1.57e-06 GO:0072359 circulatory system development
1.65 1.81e-06 GO:0048858 cell projection morphogenesis
1.27 1.89e-06 GO:0048522 positive regulation of cellular process
1.41 2.44e-06 GO:0010604 positive regulation of macromolecule metabolic process
2.90 2.99e-06 GO:0007519 skeletal muscle tissue development
1.78 3.27e-06 GO:0007389 pattern specification process
1.63 3.44e-06 GO:0032990 cell part morphogenesis
1.74 3.70e-06 GO:0009792 embryo development ending in birth or egg hatching
1.74 3.75e-06 GO:0043009 chordate embryonic development
1.68 4.01e-06 GO:0032583 regulation of gene-specific transcription
2.25 4.23e-06 GO:0007156 homophilic cell adhesion
1.20 5.08e-06 GO:0023052 signaling
2.81 5.19e-06 GO:0060538 skeletal muscle organ development
1.39 5.42e-06 GO:0031325 positive regulation of cellular metabolic process
2.62 7.15e-06 GO:0048706 embryonic skeletal system development
1.77 7.30e-06 GO:0045597 positive regulation of cell differentiation
1.64 1.13e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.76 1.32e-05 GO:0007411 axon guidance
2.77 1.47e-05 GO:0051147 regulation of muscle cell differentiation
1.71 1.69e-05 GO:0048598 embryonic morphogenesis
1.43 1.76e-05 GO:0042127 regulation of cell proliferation
1.71 2.10e-05 GO:0007420 brain development
1.27 3.46e-05 GO:0048523 negative regulation of cellular process
2.05 5.77e-05 GO:0009952 anterior/posterior pattern formation
1.43 6.67e-05 GO:0040011 locomotion
1.25 7.29e-05 GO:0048519 negative regulation of biological process
1.50 7.70e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.20 9.37e-05 GO:0060255 regulation of macromolecule metabolic process
1.74 9.62e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.23 9.79e-05 GO:0010468 regulation of gene expression
1.24 1.19e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.89 1.22e-04 GO:0070848 response to growth factor stimulus
1.83 1.23e-04 GO:0050767 regulation of neurogenesis
2.10 1.34e-04 GO:0050678 regulation of epithelial cell proliferation
1.74 1.44e-04 GO:0016337 cell-cell adhesion
1.20 1.44e-04 GO:0007165 signal transduction
1.67 1.50e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.93 1.79e-04 GO:0048732 gland development
1.75 1.80e-04 GO:0001944 vasculature development
1.63 2.01e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.45 2.10e-04 GO:0007155 cell adhesion
1.45 2.10e-04 GO:0022610 biological adhesion
2.23 2.61e-04 GO:0048736 appendage development
2.23 2.61e-04 GO:0060173 limb development
1.86 2.61e-04 GO:0043193 positive regulation of gene-specific transcription
2.03 2.79e-04 GO:0043062 extracellular structure organization
1.54 3.01e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.75 3.29e-04 GO:0051960 regulation of nervous system development
1.84 4.03e-04 GO:0048514 blood vessel morphogenesis
1.31 4.84e-04 GO:0050877 neurological system process
1.75 4.97e-04 GO:0001568 blood vessel development
1.24 5.98e-04 GO:0051252 regulation of RNA metabolic process
1.52 6.28e-04 GO:0051253 negative regulation of RNA metabolic process
2.21 6.99e-04 GO:0035107 appendage morphogenesis
2.21 6.99e-04 GO:0035108 limb morphogenesis
1.24 7.33e-04 GO:0006355 regulation of transcription, DNA-dependent
1.37 7.54e-04 GO:0007154 cell communication
2.63 8.86e-04 GO:0048634 regulation of muscle organ development
4.02 9.61e-04 GO:0048665 neuron fate specification
1.22 1.22e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.42 1.28e-03 GO:0007267 cell-cell signaling
1.84 1.37e-03 GO:0045664 regulation of neuron differentiation
1.47 1.41e-03 GO:0010629 negative regulation of gene expression
1.47 1.42e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.63 1.50e-03 GO:0016202 regulation of striated muscle tissue development
1.46 1.90e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.76 2.07e-03 GO:0048568 embryonic organ development
1.90 3.39e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.54 3.64e-03 GO:0048704 embryonic skeletal system morphogenesis
2.01 3.79e-03 GO:0048705 skeletal system morphogenesis
1.45 4.20e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.15 4.46e-03 GO:0051716 cellular response to stimulus
3.05 4.67e-03 GO:0051153 regulation of striated muscle cell differentiation
1.99 4.91e-03 GO:0042692 muscle cell differentiation
2.95 4.97e-03 GO:0001708 cell fate specification
1.90 5.06e-03 GO:0048562 embryonic organ morphogenesis
2.37 5.59e-03 GO:0008584 male gonad development
1.66 6.00e-03 GO:0007423 sensory organ development
2.23 6.04e-03 GO:0046546 development of primary male sexual characteristics
1.48 6.96e-03 GO:0006935 chemotaxis
1.48 6.96e-03 GO:0042330 taxis
1.41 7.14e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.19 7.73e-03 GO:0031326 regulation of cellular biosynthetic process
1.71 7.74e-03 GO:0007507 heart development
1.36 7.84e-03 GO:0006351 transcription, DNA-dependent
2.73 8.36e-03 GO:0048663 neuron fate commitment
1.17 8.76e-03 GO:0016043 cellular component organization
1.21 9.04e-03 GO:0042221 response to chemical stimulus
1.42 9.21e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
2.49 9.36e-03 GO:0050680 negative regulation of epithelial cell proliferation
1.19 1.10e-02 GO:0009889 regulation of biosynthetic process
1.16 1.19e-02 GO:0080090 regulation of primary metabolic process
1.64 1.23e-02 GO:0035295 tube development
1.84 1.27e-02 GO:0001525 angiogenesis
2.14 1.31e-02 GO:0046661 male sex differentiation
2.97 1.44e-02 GO:0048641 regulation of skeletal muscle tissue development
1.52 1.48e-02 GO:0016477 cell migration
2.27 1.63e-02 GO:0022612 gland morphogenesis
1.19 1.69e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.46 1.77e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.81 1.94e-02 GO:0045137 development of primary sexual characteristics
1.45 2.10e-02 GO:0008284 positive regulation of cell proliferation
1.48 2.31e-02 GO:0048870 cell motility
1.48 2.31e-02 GO:0051674 localization of cell
1.19 2.35e-02 GO:0071842 cellular component organization at cellular level
2.73 2.44e-02 GO:0051149 positive regulation of muscle cell differentiation
1.38 2.61e-02 GO:0009890 negative regulation of biosynthetic process
1.14 2.64e-02 GO:0019222 regulation of metabolic process
1.66 2.68e-02 GO:0040007 growth
4.19 3.07e-02 GO:0060428 lung epithelium development
2.55 3.33e-02 GO:0021510 spinal cord development
2.23 3.76e-02 GO:2000027 regulation of organ morphogenesis
2.08 3.80e-02 GO:0030326 embryonic limb morphogenesis
2.08 3.80e-02 GO:0035113 embryonic appendage morphogenesis
1.89 4.01e-02 GO:0001503 ossification
1.87 4.11e-02 GO:0048589 developmental growth
2.80 4.31e-02 GO:0071363 cellular response to growth factor stimulus
1.44 4.38e-02 GO:0048585 negative regulation of response to stimulus
1.32 4.57e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.15 4.93e-02 GO:0071840 cellular component organization or biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.84 4.59e-08 GO:0005578 proteinaceous extracellular matrix
1.77 4.68e-08 GO:0031012 extracellular matrix
1.41 8.07e-07 GO:0044421 extracellular region part
2.16 3.97e-05 GO:0030016 myofibril
2.17 4.73e-05 GO:0044449 contractile fiber part
1.16 5.71e-05 GO:0005886 plasma membrane
1.16 8.98e-05 GO:0071944 cell periphery
2.08 1.08e-04 GO:0043292 contractile fiber
1.47 1.52e-04 GO:0030054 cell junction
1.24 1.70e-04 GO:0005576 extracellular region
1.38 7.10e-04 GO:0005615 extracellular space
2.11 1.02e-03 GO:0030017 sarcomere
1.98 2.95e-03 GO:0044420 extracellular matrix part
1.20 5.88e-03 GO:0044459 plasma membrane part
1.47 1.24e-02 GO:0045202 synapse
1.22 2.55e-02 GO:0005856 cytoskeleton
1.43 4.07e-02 GO:0043005 neuron projection
2.57 4.18e-02 GO:0005581 collagen
1.29 4.20e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.56 4.38e-12 GO:0001071 nucleic acid binding transcription factor activity
1.56 4.38e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.67 8.50e-12 GO:0043565 sequence-specific DNA binding
1.54 1.58e-11 GO:0030528 transcription regulator activity
1.56 1.85e-07 GO:0005509 calcium ion binding
1.10 2.19e-04 GO:0005515 protein binding
1.60 1.07e-03 GO:0003779 actin binding
1.53 3.21e-03 GO:0000988 protein binding transcription factor activity
1.53 3.21e-03 GO:0000989 transcription factor binding transcription factor activity
1.52 5.00e-03 GO:0003712 transcription cofactor activity
1.42 7.17e-03 GO:0008092 cytoskeletal protein binding
1.75 2.32e-02 GO:0008083 growth factor activity
2.32 3.39e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.35 3.94e-02 GO:0003707 steroid hormone receptor activity
1.51 4.86e-02 GO:0016564 transcription repressor activity